Michael Reese Endowed Professorship in Urology

Gail S. Prins, PhD

Dr. Prins is enormously grateful for the prominence and research opportunities that are afforded to her as the Michael Reese Professor of Urology at the University of Illinois at Chicago. Many doors have been opened and new discoveries have been made as a result of the research support provided by the Michael Reese Research and Education Foundation. She has now completed an exciting new study analyzing single cell transcriptomes (gene expression within individual cells) of human prostate stem and progenitor cells from both

normal prostates and prostate cancers. Bioinformatic comparisons of active genes between the normal and cancerous stem cell populations are expected to identify actionable targets for prostate cancer therapeutics.

Top accomplishments:



Recent News:


Easton, John. “NIH taps Chicago universities for center on environmental health.” Science Life [Chicago] 26 September 2017. https://sciencelife.uchospitals.edu/2017/09/26/nih-taps-chicago-universities-for-center- on-environmental-health/


“NIH taps Chicago universities for center on environmental health.” UIC Today

[Chicago] 4 October 2017.

https://today.uic.edu/nih-taps-chicago-universities-for-center-on-environmental-health


WTTW Chicago Tonight http://bit.ly/2wVW9IU



Conferences:


Keynote Lecture, Pittsburgh O’Brien Urology Research Center; Symposium on LUTS and BPH, “Prostate stem cells as hormone targets in the regulation of homeostasis and disease susceptibility”, June 19, 2017

FASEB Summer Research Conference: Rapid Signaling & Genomic Hormone Action in Health & Disease. June 11-16, 2017, Snowmass Village, Colorado, “Cross-talk between estrogen receptors and insulin-like growth factor type 1 receptor modulates human prostate stem/progenitor cell amplification.”

Frontiers in Reproduction Summer Workshop, June 1-4, 2017, Marine Biological Laboratory, Woods Hole, MA: Lecture: “Prostate Development, Growth and Function; Normal and Abnormal”. Laboratory Workshop: Developing prostate gland cultures.

Keynote Lecture, Center for Molecular Carcinogenesis and Toxicology Symposium, University of Texas at Austin, May 18, 2017, “Prostate stem cells as EDC and arsenic targets that lead to increased cancer susceptibility.”

Northwestern University, Center for Reproductive Science, Chicago, IL, May 8, 2017. “Estrogenic Signaling as Key Regulators of Prostate Stem Cells”.

Mekele University, Ethiopia, Dept Ob/Gyn, March 4-10, 2017. “Male Reproductive Anatomy & Physiology”, “Male Infertility”, and “Semen Analysis”.

11th Annual National Symposium on Prostate Cancer, Sept 26-28, 2016, Clark Atlanta University, Atlanta, GA, “Estrogen signaling and activity in human prostate stem and progenitor cells”


NIEHS: 25 Years of Endocrine Disruption Research: Past Lessons and Future Directions, Sept 18-20, 2016, NIH campus, Bethesda, MD, “Overview: Mechanisms and Health Effects of Endocrine Disrupting Chemicals”

Published papers:


Cooke P, Nanjappa M, Ko CJ, Prins GS, Hess R (June 2017): Estrogens in Male Physiology. Physiological Reviews 97:995-1043, 2017

Kathrins M, Abhyankar N, Shoshany O, Liebermann J, Uhler M, Prins G, Niederberger C (May 2017). Post-thaw recovery of rare or very low concentrations of cryopreserved human sperm. Fertility and sterility, 107(6): 1300-1304.


George JW, Patterson AL, Tanwar PS, Kajdacsy-Balla A, Prins GS, Teixeira JM (March 2017). Specific deletion of LKB1/ Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice.

Proceedings of the National Academy of Sciences, 114(13):3445-3450


Sharif A, Malhotra NR, Acosta AM, Kajdacsy-Balla AA, Bosland M, Guzman G, Prins GS, Abern MR (February 2017). The Development of Prostate Adenocarcinoma in a Transgender Male to Female Patient: Could Estrogen Therapy Have Played a Role?: Estrogen and Prostate Cancer Development. The Prostate 77:824-8.

Shah P, Trinh E, Qiang L, Xie L, Hu WY, Prins GS, Pi J, He YY (January 2017). Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules, 22(2):194.

Kobori Y, Pfanner P, Prins GS, Niederberger C (Nov 2016): Novel device for male infertility screening with single-ball lens microscope and smartphone. Fertil Steril, 106(3):574-578 2016.

Vandenberg LN, Prins GS (july 2016): Clarity in the face of confusion: New studies tip the scales on bisphenol A (BPA). Andrology, 4:561-564, 2016.

Cheong A, Zhang X, Cheung YY, Tang WY, Chen J, Ye SH, Medvedovic M, Leung RY, Prins GS, Ho SM (July 2016). DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics, 11(9):00-00.